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M9480825.TXT
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1994-09-05
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Document 0825
DOCN M9480825
TI HIV p24 antigen (Ag) in the CSF using immune complex dissociation (ICD):
correlation with p24 antibodies (Ab) in CSF, CD4, and cerebral atrophy.
DT 9410
AU Valdez LM; Donovan RM; Mateo NB; Manzor O; Baxa D; Markowitz NP;
Saravolatz LD; Department of Infectious Diseases, Henry Ford Hospital,
Detroit,; Michigan.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:622 (abstract no. V-30). Unique
Identifier : AIDSLINE ASM94/94313120
AB The central nervous system is a major target for HIV infection. Studies
have suggested that p24 Ag in the CSF is associated with the AIDS
Dementia Complex (ADC). We studied 22 HIV infected patients for the
presence of p24 Ag and correlated these findings with the presence of
p24 Ab, cerebral atrophy by CT or MRI, and CD4 count. HIV p24 Ag was
measured in plasma and CSF with and without ICD (Coulter). CSF p24 Ab
was determined using western blot (Dupont). ICD detected 5 patients with
positive p24Ag (22.7%) but only 3 of these patients (13.6%) were
detected by the free method. Cerebral atrophy was demonstrated in all 5
patients with CSF p24 Ag, but in only 2 of 17 patients who were CSF p24
Ag negative (p < 0.001). Western blot detected CSF p24 Ab in 9
individuals. All the patients with p24 Ab, were p24 Ag negative in their
CSF (p = 0.056). Only 1 of these 9 showed evidence of cerebral atrophy.
Neither the presence or the magnitude of plasma p24 Ag (with or without
ICD) correlated with CSF findings or cerebral atrophy. The mean CD4 in
patients who had positive CSF p24 Ag was 9 +/- 6.2 cells/microliters,
compared to 103.9 +/- 165.09 cells/microliters in the patients with a
negative Ag. In conclusion: 1) ICD increases the sensitivity of p24 Ag
detection in the CSF. 2) The presence of HIV p24 Ag in the CSF (free or
ICD) was associated with cerebral atrophy; 71% of those with cerebral
atrophy had detectable p24 Ag in their CSF. Therefore CSF ICD p24 Ag may
be of value in the diagnosis of ADC.
DE Age Factors *Antigen-Antibody Complex Atrophy AIDS Dementia
Complex/*CEREBROSPINAL FLUID/*DIAGNOSIS/PATHOLOGY Brain/*PATHOLOGY
Comparative Study Human HIV Antibodies/*ANALYSIS/BLOOD/*CEREBROSPINAL
FLUID HIV Core Protein p24/*CEREBROSPINAL FLUID/IMMUNOLOGY HIV
Infections/*CEREBROSPINAL FLUID/PATHOLOGY Sensitivity and Specificity
T4 Lymphocytes/*MICROBIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).